Stealth and Cover
Do not sprint through open, highly visible areas. Use low-visibility routes and walk along walls to avoid leaving tracking trails for Villains like A-Train or Omni-Man. Dark corners in the Residential Block map are your best friend.
Sledgehammer Traversals
Use the Sledgehammer to break through structural walls and escape tight spaces. Sledgehammers have infinite uses on map obstacles, allowing you to create custom escape routes that the Villain may not expect.
Countering A-Train's Drag
A-Train's Drag execute is the most dangerous single-target attack in the game. Stay within 6 studs of a teammate when A-Train is the active Villain so that Whirlwind can be evaded by splitting up. Never isolate yourself in an open room.
Dodging Homelander Lasers
Homelander's Laser Eyes have a 0.8 second windup. As soon as you hear the audio cue, sidestep perpendicular to his facing direction. Standing still is the worst possible choice.